癌症科学类最新新闻

癌症科学类最新20条新闻

Oregon Health&Science University Cancer Institute researchers have found that an experimental drug known as SGX393 is effective against Gleevec-resistant chronic myeloid leukemia. The results of their study will be published the week of March 24 in the Proceedings of the National Academy of Sciences.

A review of cancer screening studies shows that white women who are obese are less likely than healthy weight women to get the recommended screenings for breast and cervical cancer, according to researchers at the University of North Carolina at Chapel Hill's School of Public Health.

Physicians at St. Jude Children's Research Hospital have demonstrated that children with bilateral Wilms tumor, a cancer of the kidneys, can retain normal function in both kidneys by undergoing a procedure called bilateral nephron-sparing surgery, even when preoperative scans suggest that the tumors are inoperable.

New data, to be published in the May print issue of the Journal of Clinical Investigation, have characterized a molecular pathway underlying low-grade forms of a type of brain tumor known as an astrocytoma. The authors therefore suggest that therapeutics targeting this pathway might provide a new approach to treating individuals with low-grade atrocytomas.

This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, April 8, 2008, in the JCI: Small molecule miRNAs regulate female mouse fertility; Too many gene copies stimulate tumor cell growth; Too much of a good thing: high levels of factor VIIa cause problems in mice; A pox on TLR9: the immune molecule TLR9 is crucial to prevent lethal poxvirus infection in mice; and others.

Recent studies have suggested an association between chronic inflammation and cancers of the prostate, colon, stomach and liver. Now scientists report success in blocking an early step in metastasis of prostate cancer cells by interrupting the communication between the cancer cells and other cells that promote inflammation.

A Sargent, A Bailey, M Almonte, A Turner, C Thomson, J Peto, M Desai, J Mather, S Moss, C Roberts&H C Kitchener

N Moniaux, S Chakraborty, M Yalniz, J Gonzalez, V K Shostrom, J Standop, S M Lele, M Ouellette, P M Pour, A R Sasson, R E Brand, M A Hollingsworth, M Jain&S K Batra

L G Spector, K J Johnson, J T Soler&S E Puumala

By increasing production of a blood pressure-regulating enzyme in mice, researchers have found they can enhance the mouse immune system's ability to sense tumor growth. When scientists engineered mice that make more angiotensin-converting enzyme in white blood cells called macrophages, the mice could more effectively limit the growth of injected tumors.

A unique partnership between industry and academia has led to human clinical trials of a new drug for a rare class of blood diseases called myeloproliferative disorders, which are all driven by the same genetic mutation and can evolve into leukemia.

Researchers from the European Molecular Biology Laboratory in Italy, the EMBL-European Bioinformatics Institute, UK, and the Universities of Harvard, USA, and Lund, Sweden, have now used genetic engineering to introduce a mutation found in human leukemia patients into mice. In the current issue of Cancer Cell they report that the mutation causes leukemia by triggering innate genetic programs that allow white blood cells to proliferate uncontrollably. The findings have implications for the way leukemia should be treated.

Researchers at Dana-Farber Cancer Institute and Memorial Sloan-Kettering Cancer Center have developed a new algorithm for ranking abnormal genes according to their likelihood of contributing to a cancer. They also show that a gene identified by the algorithm as a likely restrainer of tumor growth does indeed play that role in a common type of brain cancer, and is not a mere "bystander" to another restrainer gene.

A study of 100,000 nurses suggests that their risk of developing breast cancer was the same regardless of the amount of acrylamide in their diet

Attaching a photodynamic cancer drug to a cancer-specific antibody fragment has increased the drug's potency and reduced its side effects

An initiative to combat cancer in the enlarged European Union has been adopted in a plenary session of the European Parliament today (Thursday, April 10). The adoption of the Cancer Resolution has been welcomed by ECCO -- the European CanCer Organization, which says that patients, and all those who care for them, will benefit if the European Commission and Member States take action on the resolution's 40 proposals.

Contrary to the currently accepted model of T-cell development, researchers have found that juvenile cells on their way to becoming mature immune cells can develop into either T-cells or other blood-cell types versus only being committed to the T-cell path.

Metastasis, the spread of cancer from a primary site to other tissues and organs in the body, is the leading cause of death among cancer patients. Without an animal model that consistently reproduces human-like metastasis, researchers have relied on individual cancer patients to assess new therapies. Boston College researchers unveil a new mouse model they used it to make a new finding about the role of macrophage cells in the spread of cancer.

A new study suggests that a genetic fingerprint associated with normal embryonic stem cells may be important for the development and function of cancer stem cells.

Another piece of the puzzle that is breast cancer has been found by University of Queensland researchers.